A STRUCTURAL APPROACH TO DISCOVERY

Xtal BioStructures specializes in X-ray crystallography and biophysical characterization, offering structural biology insights through contract research services.
PROTEIN PRODUCTION AND PURIFICATION
XTAL produces high quality proteins, custom designed to meet the needs of our clients in X-ray crystallography, biophysical characterization, screening, and assay development applications.

BIOPHYSICAL CHARACTERIZATION
XTAL offers characterization of protein:ligand interactions via SPR, ITC, and TSA (DSF). Applications include characterization of ligand binding kinetics, fragment-based screening, optimization of protein storage conditions, and pre-formulation.

X-RAY CRYSTALLOGRAPHY
XTAL offers high resolution protein structure determination of proteins, protein/small molecule/antibody complexes, and novel structures with data from synchrotron X-ray sources.

EPIGENETIC and BROMODOMAIN PROTEINS
XTAL produces higher order nucleosome core particle complexes and a broad array of bromodomain proteins.

OTHER SERVICES
XTAL offers a broad array of scientific expertise, implementing various programs such as assay development and mechanism of action studies.