Biophysical Characterization for the measurement of ligand:protein interactions using thermal stability shift, SPR and ITC. Applications include confirmation of ligand binding, fragment based screening, identification of optimal storage conditions, binding kinetics Kd and pre-formulation.
X-Ray Crystallography with synchrotron data collection for highest resolution of co-crystal structures of small molecule-protein complexes, antibody-antigen and novel structure determinations.
Epigenetic & Bromodomains – Production of higher order complexes of nucleosome core particles and a broad array of bromodomain proteins for screening, biophysical, structural and selectivity panel applications.
Other Services include programs that are more difficult to define requiring a broad scientific array of expertise, assay development and mechanism of action studies.