About Us

Xtal BioStructures, Inc. (XTAL) was founded in 2005 as a contract research organization (CRO) to provide numerous services to the pharmaceutical and biotechnology industries. Our focus is on high quality science and communication, providing our expertise in protein production and biophysical methods to enable drug screening, optimization, and development.

In order to enable proof-of-concept experiments and drug discovery programs, we produce well characterized proteins of high purity. We then offer a pipeline of affinity based biophysicial measurements for screening and drug optimization through the methods of Thermal Stability Assays (TSA) and Isothermal Titration Calorimetry (ITC), and generate high resolution  X-ray crystal structures.  We then offer consulting and computational services on the understanding and insights that may be obtained from the perspective of the protein at a molecular level.

Our team is highly experienced and many members have been trained in multiple disciplines to provide our clients with the maximum amount of flexibility.

At XTAL, we believe that communication is a critical factor in achieving the best possible outcome. As such, we strive to develop and maintain a strong channel of open communication between our clients and ourselves throughout the process.

We are located at 12 Michigan Drive, Natick, MA 01760 USA.