Xtal BioStructures, Inc. (XTAL) was founded in 2005 to provide numerous services to the pharmaceutical and biotechnology industries. Our focus is on high quality science and communication, providing our expertise in protein production and biophysical methods to enable drug screening, optimization, and development.

In order to enable proof-of-concept experiments and drug discovery programs, we produce well characterized proteins of high purity. We then offer a pipeline of affinity-based biophysicial measurements for screening and drug optimization through the methods of Thermal Stability Assays (TSA), Surface Plasmon Resonance (SPR), and Isothermal Titration Calorimetry (ITC). Our team generates high resolution X-ray crystal structures to provide structural insights into your pharmaceutical or biotherapeutic program. Our capacity is now expanding into providing cryo-EM structural characterization as the field rapidly advances. Consulting and computational services provide further understanding and insights into what may be obtained from the perspective of the protein at a molecular level.

Our team is highly experienced, with members trained in multiple disciplines to provide our clients with the maximum amount of flexibility.

At XTAL, we believe that communication is a critical factor in achieving the best possible outcome. As such, we strive to develop and maintain a strong channel of open communication between our clients and ourselves throughout the process.